Almost 25% of women with breast cancer have a family history of the disease and, those who do have a higher risk of developing cancer.
Almost 25% of women with breast cancer have a family history of the disease, and women with an affected first-degree relative have a 1.75-fold higher risk of developing cancer.1 That risk increases to 2.5-fold with two or more affected first-degree relatives. Multiple genes have been identified that are associated with breast cancer. While BRCA1 and BRCA2 have received much attention as they are linked to 20% to 25% of hereditary breast cancers and 5% to 10% of all breast cancers, 6 genetic testing has expanded to include 28 genes. The above table presents the National Comprehensive Cancer Network (NCCN) guidelines for genetic testing. Genetic counselors can be a good referral source, should there be a need for genetic testing. If no genetic counselor is available in your area, then referral to a breast surgeon is appropriate to discuss family history as well as a patient’s lifetime risk of breast cancer and need for genetic testing.
For more information on breast health:
Optimizing breast health
Exogenous hormones and patients at increased risk for breast cancer
October 17th 2023This lecture, presented by Holly J. Pederson, MD, at The Menopause Society 2023 Annual Meeting, looked at combined oral contraceptives in BRCA carriers and other high-risk patients, and hormone therapy in postmenopausal gene carriers as well as other high-risk women.
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